Leukodystrophies - Mri

Checklist

• Location of white matter abnormalities

• Signal of white matter apart from the affected regions (hypomyelination)

• Cavitation

• Cerebellar involvement

• Head size

• Contrast enhancement

Characteristic Features Of Various Leukodystrophies On MRI

• Macrocephaly is seen in Krabbe's, Alexander's, Canavan's, Hurler syndrome

• White matter changes located posteriorly: ALD

• White matter changes located anteriorly: Alexander's disease

• Periventricular involvement: MLD, ALD

• Involvement of arcuate fibers: Canavan's disease

• High density basal ganglia: Krabbe's disease

• Post contrast enhancement is seen in ALD, Alexander

Alexander's Disease (Fig 1)

MLD (Fig 2)

ALD (Fig 3)

Infantile onset leukoencephalopathy (Vacuolation/spongiform changes) (Fig 4)