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Posted On : 12 Aug 2014

can we use Deflazacort in nephrotic syndrome .give detailed guideline,where can i get reference

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Answer 1

Dear Sir, Madam
Unfortunately I do not have an personal experience with the use of this agent in NS. These references may help you:
Drugs. 1995 Aug`50{2}:317-33.

Deflazacort. A review of its pharmacological properties and therapeutic efficacy.
Markham A, Bryson HM.

Adis International Limited, Auckland, New Zealand.
Pediatr Nephrol. 1997 Aug`11{4}:418-22.

A controlled study of Deflazacort in the treatment of idiopathic nephrotic syndrome.
Broyer M, Terzi F, Lehnert A, Gagnadoux MF, Guest G, Niaudet P.

Département de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Paris, France.

Forty patients with steroid-dependent idiopathic nephrotic syndrome {INS}, a mean follow-up of 5.5 years, and a mean number of relapses of ten were blindly assigned to either Deflazacort {DFZ} {n = 20} or prednisone {PDN} {n = 20} according to a ratio of equivalence of DFZ, PDN = 0.8. This treatment was given for 1 year. The number of relapses was significantly lower in patients receiving DFZ. After 1 year, 12 remained in remission with DFZ compared with 2 with PDN. Growth velocity was not different in the two groups. Bone mineral content, assessed by quantitative computed tomography of L1 L2 vertebrae, decreased after 1 year by 6 percent in the DFZ group versus 12 percent in the PDN group {NS}. The mean body weight increase of plus3.9 plus, - 4.1 kg in the PDN group was higher than that of the DFZ group, plus1.7 plus, - 2.8 kg {P = 0.06}. Cushingoid symptoms tended to be less after 12 months in the DFZ group. In conclusion, this study shows that DFZ was more effective than PDN in limiting relapses in steroid-dependent INS, and that cushingoid symptoms, weight gain, and decrease in bone mineral content tended to be less marked with this drug than with PDN.

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