Ticarcillin
Mechanism :
It is an extended spectrum, semisynthetic penicillin. It is active against both gram-positive and gram-negative bacteria with a good antipseudomonal activity. It is used in treating severe infections associated with pseudomonas.
Indication :
- Treatment of bacterial infections
Contraindications :
Hypersensitivity to drug/class/component.
Anaphylactic reaction to beta-lactams.
Dosing :
IV
Neonates <7 days old, <2 kg or >7 days old, <1.2 kg: 75 mg/kg/dose every 12 hours.
Neonates <7 days old, >2 kg or >7 days old, 1.2-2 kg: 75 mg/kg/dose every 8 hours.
Neonates >7 days old, >2 kg: 100 mg/kg/dose every 8 hours.
Full-term neonates and above: 200-300 mg/kg/day IV divided every 4-6 hours.
>60 kg: 3 g IV every 4-6 hours.
Adverse Effect :
Decreased platelet aggregation, hypernatremia, hypocalcemia, rash, increased liver enzymes, thrombophlebitis, seizure, Jarisch-Herxheimer reaction, hemolytic anemia, Positive coomb’s test, acute interstitial nephritis.
Interaction :
Ticarcillin
Penicillin, extended-spectrum
Interaction Characteristics:
Alters GI flora, antiplatelet effects, bactericidal activity requires bacterial growth, lowers seizure threshold.
Contraindicated:
BCG live intravesical.
Hepatic Dose :
There are no pediatric specific recommendations; based on experience in adult patients, dosing adjustment suggested with concomitant renal dysfunction.