Tetanus Immunoglobulin
Synonym :
TIG
Mechanism :
It is a human serum preparation containing antibodies against tetanus. These gamma globulins protect against tetanus infections. It is given for prevention and for active immunization along with tetanus toxoid.
Indication :
- Passive, transient protection against tetanus when:
- Patient’s personal history of immunization with tetanus toxoid is unknown or uncertain,
- Person received less than 2 prior doses of tetanus toxoid, or
- Person received 2 prior doses of tetanus toxoid, but delay of more than 24 hr occurred between time of injury and initiation of tetanus prophylaxis.
Contraindications :
Hypersensitivity to human antibody product, thimerosal, or other components; circulating anti-IgA antibodies.
Dosing :
IM Dose is calculated on basis of body weight (4 units/kg); however, it may be advisable to administer 250 units regardless of the size of the child.
Adverse Effect :
Pain, tenderness, muscle stiffness at injection site, persisting for several hours. Hives, angioedema, nephrotic syndrome, and local inflammation occur occasionally. Anaphylactic reactions (rare). Fever, lethargy, chest tightness may occur.
Interaction :
There is no significant interaction between TIG and tetanus toxoid if given at different injection sites. To avoid inactivating vaccines containing live viruses or bacteria, give live vaccines 2 to 4 weeks before or 12 wk after TIG.
Hepatic Dose :
No dosage adjustments are recommended.