Tenofovir Disoproxil Fumarate
Synonyms :
TDF, Tenofovir DF
Indication :
- HIV infection
- Chronic Hepatitis B
Dosing :
HIV Infection:
2-12 years: 8 mg/kg orally once a day, Maximum: 300 mg/day.
>12 years: 300 mg OD.
Chronic Hepatitis B:
≥12 years, ≥35 kg: 300 mg orally once a day.
The optimum duration of treatment is not known.
Adverse Effect :
Asthenia, diarrhea, nausea, pain, anorexia, depression, myalgia, peripheral neuropathy, dyspepsia, rash, headache, vomiting, flatulence, abdominal pain, neutropenia, increased transaminases, new onset or worsening renal impairment, lactic acidosis, decreased bone mineral density.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 30-50 | 245 mg every 48 hours |
| 10-30 | 245 mg every 72–96 hours |
| <10 | 245 mg every 7 days |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Unknown dialysability. Dose as in GFR<10 mL/min |
| HD | Dialysed. Dose as in GFR<10 mL/ min |
| HDF/High flux | Dialysed. Dose as in GFR<10 mL/ min |
| CAV/VVHD | Dialysed. Dose as in GFR=10– 30 mL/min |
Hepatic Dose :
No dose adjustment recommended. Use cautiously in patients with liver disease due to risk of hepatotoxicity.