Sodium Sulphacetamide

Synonyms :

Sodium Sulfacetamide, Sulphacetamide Sodium

Mechanism :

Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth (according to the Woods-Fildes theory). The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Indication :

Seborrheic dermatitis
Acne vulgaris
Conjunctivitis, corneal ulcer and other superficial ophthalmic infections caused by susceptible organisms (ophthalmic solution)
Treatment of secondary bacterial skin and skin structure infections

Contraindications :

Hypersensitivity to sulfa drugs Do not use over large skin areas Do not use on open wounds Children under 12 years of age

Dosing :

Seborrheic dermatitis, acne vulgaris:

Available as 10% topical cream and gel.

>12 years:

Apply topically to affected areas twice daily for 8 to 10 days. As conditions subsides, the interval between applications may be lengthened. Use 1 to 2 times weekly or every other week may prevent recurrence.

Conjunctivitis, corneal ulcer and other superficial ophthalmic infections caused by susceptible organisms:

Instill 1 drop (30% ophthalmic solution) to the affected eyes every 2 hours for conjunctivitis or corneal ulcers. For trachoma, instill 2 drops every 2 hours in conjunction with systemic sulfonamide therapy.

Apply a small amount (10% ophthalmic ointment) to the affected eyes 4 times per day and at bedtime.

Treatment of secondary bacterial skin and skin structure infections:

Available as 10% topical cream and gel.

Apply to the affected area 2-4 times daily until the infection has cleared.

Adverse Effect :

Erythema, rash, malar rash, joint pain, pallor, nausea, epigastric discomfort.

Interaction :

Silver sulfadiazene Monitor all other concomitantly administered drugs

Hepatic Dose :

No dosage adjustments are recommended.