Setmelanotide
Mechanism :
Melanocortin-4 receptor agonist made to replanish impaired MC4R pathway function affected by genetic variants that occur upstream of the receptor
Indication :
- In patients with obesity cause of Bardet-Biedl syndrome, leptin receptor deficiency, proopiomelanocortin deficiency.
Contraindications :
No contraindications listed
Dosing :
≥6 years and <12 years:
Subcutaneously 1 mg once a day for two weeks then adjust dosing based on efficacy.
≥12 years:
Subcutaneously 2 mg once a day for two weeks then adjust dosing based on efficacy.
Adverse Effect :
Depression, Suicidal ideation, priapism, female sexual disorder, skin hyperpigmentation, alopecia, abdominal pain, nausea, vomiting
Interaction :
Lactation :
Not recommended
Hepatic Dose :
No significant interactions
Pregnanacy :
Not recommended