Retapamulin
Mechanism :
Primarily bacteriostatic; inhibits normal bacterial protein biosynthesis by binding at a unique site (protein L3) on the ribosomal 50S subunit.
Indication :
- Treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible isolates only)
- Streptococcus pyogenes in pediatric patients 9 months and older.
Contraindications :
No contraindications.
Dosing :
Apply a thin layer of ointment (1%) to affected area twice daily for 5 days;
Maximum:
Total treatment area should not exceed 2% of total body surface area.
Adverse Effect :
Headache, eczema, diarrhea, nausea, application site irritation, nasopharyngitis.
Interaction :
CYP3A4 Inhibitors: May increase the serum concentration of Retapamulin.
Hepatic Dose :
No dose adjustment recommended.