Protein C Concentrate
Mechanism :
Converted to activated protein C (APC). APC is a serine protease which inactivates factors Va and VIIIa, limiting thrombotic formation.
Indication :
- Severe congenital protein C deficiency:
Contraindications :
No contraindications.
Dosing :
IV
Acute episode/short-term prophylaxis:
Initial dose: 100 to 120 units/kg IV. Subsequent 3 doses: 60 to 80 units/kg every 6 hours (adjust to maintain peak protein C activity of 100%). Maintenance dose: 45 to 60 units/kg every 6 or 12 hours (adjust to maintain recommended maintenance trough protein C activit
Long-term prophylaxis:
Maintenance dose: 45 to 60 units/kg IV every 12 hours (recommended maintenance trough protein C activity levels >25%).
Adverse Effect :
Major haemorrhage, hypersensitivity reaction, diaphoresis, injection site reaction, restlessness.
Interaction :
Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): May enhance the anticoagulant effect of Anticoagulants.
Estrogen Derivatives and progestins: May diminish the anticoagulant effect of Anticoagulants.
Nonsteroidal Anti-Inflammatory Agents: May enhance the anticoagulant effect of Anticoagulants.
Thrombolytic Agents: May enhance the anticoagulant effect of Anticoagulants.
Hepatic Dose :
effects not studied.