Potassium Phosphate

Synonym :

Potassium Phosphate/Sodium Phosphate

Mechanism :

Phosphorus is involved in many biochemical functions in the body and significant metabolic and enzyme reactions in almost all organs and tissues.

Indication :

Treatment and prevention of hypophosphatemia

Dosing :

Hypophosphatemia:

Phosphorous serum level <0.5 mg/dL:

0.5 mmol/kg IV infused over 4-6 hours.

Phosphorous serum level 0.5-1 mg/dL:

0.25 mmol/kg IV infused over 4-6 hours.

Oral: Available as 126 mg/67 mg or 250 mg/298 mg or 250 mg/160 mg tablets of potassium phosphate/sodium phosphate. To give 1-2 tablets PO every 4 hours or 1 sachet/day.

Prevention of hypophosphatemia (e.g. in TPN):

Infants/children: 0.5-2 mmol/kg/day IV.

Children >50 kg or adolescents: 10-40 mmol/day IV.

Adverse Effect :

Paresthesias of the extremities, Flaccid paralysis, Listlessness, Mental confusion, Weakness and heaviness of the legs, Hypotension, Cardiac arrhythmias, Heart block, hypocalcemic tetany.

Interaction :

Antacids: May decrease the serum concentration of Potassium Phosphate.
Potassium-Sparing Diuretics: Potassium Salts may enhance the hyperkalemic effect of Potassium-Sparing Diuretics.
Magnesium Salts: May decrease the serum concentration of Phosphate Supplements.
Calcium Salts: May decrease the absorption of Phosphate Supplements.
Iron Salts: May decrease the absorption of Phosphate Supplements.

Hepatic Dose :

Use with caution.