Pegademase
Mechanism :
Pegademase bovine is a (modified) enzyme replacement for adenosine deaminase deficiency.
Indication :
- For enzyme replacement therapy for adenosine deaminase (ADA) deficiency with SCID
Contraindications :
As preparatory or support therapy for bone marrow transplantation; severe thrombocytopenia.
Dosing :
IM:
Initial dosage: 10 units/kg for the first dose, 15 units/kg for the second dose, and 20 units/kg for the third dose; administer dose every 7 days; maintenance dose: 20 units/kg/week; increase by 5 units/kg/week if necessary; maximum single dose: 30 units/kg.
Adverse Effect :
Antibody development, Autoimmune hemolytic anemia, erythema at injection site, headache, hemolytic anemia, immune thrombocytopenia, malignant lymphoma, pain at injection site, thrombocythemia, thrombocytopenia, urticaria.
Interaction :
Pegloticase: May diminish the therapeutic effect of pegylated Drug Products.
Pentostatin: May diminish the therapeutic effect of Pegademase Bovine and vice-versa.
Hepatic Dose :
No dosage adjustments are recommended.