Tolperisone

Mechanism :

Tolperisone (HCl) is a centrally acting muscle relaxant. Tolperisone (HCl) is used in the symptomatic treatment of spasticity and muscle spasm.

Indication :

Acute or chronic treatment of pathologically elevated skeletal muscle tone in organic neurological disorders.
Treatment of muscular hypertonicity and muscle spasms associated with locomotor diseases (e.g. spondylosis, spondylarthrosis, cervical and lumbar syndromes, arthrosis of large joints).
Rehabilitation after orthopaedic and trauma surgery.
Treatment of obliterative vascular diseases as well as syndromes due to impaired vascular innervation (e.g. acrocyanosis, dysbasia angioneurotic intermittent).

Contraindications :

Tolperisone (HCl) is contraindicated in conditions like Myasthenia gravis.

Dosing :

<6 years:

5 mg/kg daily orally divided in three doses.

6-14 years:

2-4 mg/kg daily orally, divided in three doses.

Adults:

150-450 mg orally daily divided in 3 doses.

Adverse Effect :

Muscle weakness, somnolence, hypersensitivity, urticaria, pruritus, dyspnoea, angioedema, erythema, rash and anaphylactic reaction/anaphylactic shock, hyperhidrosis.

Interaction :

No interactions.

Hepatic Dose :

Individual titration with close monitoring of the patient’s condition and hepatic function is recommended in patients with moderate hepatic impairment. Use of tolperisone is not recommended in patients with severe hepatic impairment.