Mineral Oil
Mechanism :
Eases passage of stool by decreasing water absorption and lubricating the intestine; retards colonic absorption of water.
Indication :
- Temporary relief of occasional constipation (oral and rectal usage)
Contraindications :
Oral: Children <6 years, pregnancy, bedridden patients, elderly, use longer than 1 week, or difficulty swallowing.
Dosing :
Oral:
6 to <12 years:
Plain (non-emulsified) liquid: 5 to 15 mL in 24 hours (Maximum: 15 mL in 24 hours). May be taken as a single dose (at bedtime) or in divided doses.
Suspension (emulsion): 10 to 30 mL daily (Maximum: 30 mL daily). May be taken as a single dose or divided in up to 3 equal divided doses.
≥12 years:
Plain (non-emulsified) liquid: 15 to 45 mL in 24 hours. Maximum: 45 mL in 24 hours.
Suspension (emulsion): 30 to 90 mL daily. Maximum: 90 mL daily.
Adverse Effect :
Abdominal cramps, diarrhea, nausea, oily rectal leakage, vomiting.
Interaction :
Phytonadione: Mineral Oil may decrease the serum concentration of Phytonadione.
Vitamin D Analogs: Mineral Oil may decrease the serum concentration of Vitamin D Analogs.
Multivitamins/Minerals (with ADEK, Folate, Iron): Mineral Oil may decrease the serum concentrations.
Hepatic Dose :
No dose adjustments are recommended.