Methylene Blue
Mechanism :
It is used in the treatment of methemoglobinemia. It works by converting methemoglobin to a more efficient type of hemoglobin to better carry oxygen throughout the body.
Indication :
- Treatment of methemoglobinemia
- Urinary tract infections. It works as a mild antiseptic to cure the urinary tract infection
- Methylene blue is also used as a staining agent to make certain body fluids and tissues easier to view during surgery or on an x-ray.
Contraindications :
Renal Impairment, Hypersensitivity, Intraspinal or intrathecal injection, SC injection, Caution in G 6 PD deficiency.
Dosing :
1-2 mg/kg/dose of 1% solution IV over 5-30 minutes.
Repeat after one hour if required.
Adverse Effect :
Pain in extremity, chromaturia, dysgeusia, feeling hot, dizziness, hyperhidrosis, nausea, skin discolouration may occur. Vomiting, hypertension, headache, paraesthesia. Bluish discolouration of urine and faeces frequently occurs.
Interaction :
Interaction Characteristics:
Photosensitivity; serotonergic effects, strong.
Contraindicated:
Amitriptyline, Amoxapine, Bupropion, Buspirone, Citalopram, Clomipramine, Desipramine, Desvenlafaxine, Doxepin, Duloxetine, Escitalopram, Fluoxetine, Fluvoxamine, Imipramine, Isocarboxazid, Levomilnacipran, Milnacipran, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Phenelzine, Procarbazine, Protriptyline, Selegiline Transdermal, Sertraline, Tranylcypromine, Trazodone, Trimipramine, Venlafaxine, Vilazodone, Vortioxetine.
Hepatic Dose :
No dose adjustments are recommended.