Laronidase
Mechanism :
Laronidase is a recombinant (replacement) form of alpha-L-iduronidase derived from Chinese hamster cells.
Indication :
- Mucopolysaccharidosis I (Hurler syndrome, Hurler-Scheie, and Scheie forms)
Contraindications :
Severe hypersensitivity to laronidase or any component of the formulation.
Dosing :
Infants ≥6 months
IV:
0.58 mg/kg once weekly.
Adverse Effect :
Flushing, venous irritations, chills, skin rash, antibody development, injection site reaction, otitis media, infusion related reactions, hypertension, chest pain, headache, pallor, thrombocytopenia, hyperbilirubinemia, tremor.
Interaction :
No known significant interactions.
Hepatic Dose :
No dose adjustments are recommended.