Hydrogen Peroxide
Mechanism :
It acts by forming hydroxyl free radicals which are destructive to essential cell components like membrane lipids, DNA, and so on. It is a broad-spectrum and potent antimicrobial agent. The 40% topical solution made to penetrate into the SK lesion and causing oxidative damage which leads sloughing of the SK cells.
Indication :
- Seborrheic Keratosis which is not seen in pediatric population
Contraindications :
• Hypersensitivity
• Broken/inflamed skin
• Infection at the treatment site
• Intravaginal, intraoral, ophthalmic use
• Since there is no systemic absorption of the drug after topical application, exposure of the fetus/infant to the drug is not expected to happen during pregnancy/breastfeeding
Dosing :
Dosage forms: Topical solution: 40%
Seborrheic Keratosis (raised):
40% topical solution to be applied on the seborrheic keratosis lesions four times, with a gap of 1 minute, in the physician’s clinic. The unit dose applicator has to be discarded after use. A repeat treatment of the same procedure can be administered if the lesions do not completely clear till 3 weeks after treatment.
Adverse Effect :
• Common:
o 10 minutes after application: stinging, oedema, pruritis, erythema, vesiculation
o 1 week after application: crusting, pruritis, erythema, scaling
o 15 weeks after application: crusting, hyperpigmentation, erythema, scaling
• Uncommon:
o 1 week after application: erosion, ulceration
o 15 weeks after application: hypopigmentation
• Rare: eyelid oedema, herpes zoster
Hepatic Dose :
Not defined for pediatric population