Gatifloxacin
Mechanism :
Fluoroquinolone antibiotic; antibacterial action results from inhibition of DNA gyrase and topoisomerase IV
Indication :
Contraindications :
• not to be injected directly in eye chamber,
• hypersensitivity,
• pregnancy and lactation: can use
Dosing :
0.5% solution:
Day 1: one drop in affected eye every 2 hours, maximum 8 times a day.
Day 2-7: one drop in affected eye 2-4 times daily.
0.3% solution:
Day 1-2: one drop in affected eye every 2 hours, maximum 8 times a day.
Day 3-7: one drop in affected eye 2-4 times daily.
Adverse Effect :
superinfection, hypersensitivity, increased lacrimation, corneal injury with injection in the chamber of the eye,
Hepatic Dose :
No adjustment needed