Mosapride
Mechanism :
Cisapride congener having similar gastrokinetic and lower esophageal sphincter action due to 5HT-4 agonistic and 5HT-3 antagonistic action in the myenteric plexus.
Indication :
Contraindications :
Hypersensitivity; Use with caution in arrhythmic patients for fear of Q-T prolongation culminating in Torsades De Pointes.
Dosing :
0.3 mg/kg/day PO in 2-3 divided doses.
Adverse Effect :
Diarrhea, abdominal pain, headache, dizziness, insomnia.
Interaction :
Erythromycin: Plasma concentration is elevated by erythromycin and other CYP3A4 inhibitors leading to QT prolongation.
Hepatic Dose :
There are no specific recommendations in pediatric patients; based on experience in adult patients, dosage adjustment suggested.