Fidaxomicin
Mechanism :
Inhibits RNA polymerase sigma subunit resulting in inhibition of protein synthesis and cell death in susceptible organisms including C. difficile.
Indication :
- Treatment of Clostridium difficile infection.
Contraindications :
Hypersensitivity to fidaxomicin.
Dosing :
<18 years:
Safety and efficacy not established.
Adults:
Oral: 200 mg twice daily for 10 days.
Adverse Effect :
Nausea, GIT hemorrhage, abdominal pain, vomiting, anemia, neutropenia.
Interaction :
Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol.
Mizolastine: Macrolide Antibiotics may increase the serum concentration of Mizolastine.
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.
Hepatic Dose :
No dosage adjustment is recommended.