Fibrin Sealant

Mechanism :

Fibrin sealant plays a role in the last phase of physiological blood coagulation. Bleeding stops when a formed fibrin clot attaches to the wound. Some formulations contain aprotinin which enhances the resistance of the sealant clot in a fibrinolytic environment.

Indication :

• It is used as an adjunct to achieve hemostasis during surgeries when standard techniques (like suture, ligation, cauterization) to arrest bleeding fail or cannot be used.
• It is used in patients above 1 year of age, for adherence of autologous skin grafts to surgically prepared wound beds due to burns.

Dosing :

Adverse Effect :

Cardiac arrest, atrial fibrillation, bradycardia, pleural effusion, laryngeal edema, pulmonary embolism, thrombosis, GI obstruction, ileus, anaphylaxis, bronchospasm, renal failure, angioedema, constipation, bleeding, wheezing, redness, eosinophilia, ascites, hypertension, anemia, elevated liver enzymes, hypophosphatemia, tachycardia, difficulty breathing, nausea, vomiting, urticaria, itching, irritation.

Interaction :

Povidone Iodine: Povidone iodine can denature the fibrin sealant.

Lactation :

Use with caution since its secretion in milk is unknown

Hepatic Dose :

Dose adjustment not required.

Pregnanacy :

Pregnancy category C