Estrogen Conjugated
Indication :
- Delayed puberty in females
- Abnormal uterine bleeding
Dosing :
Delayed puberty in females:
0.625 mg PO OD. Start: 0.3 mg PO alternate day x 6 months and then increase every 6 months. Give 21 days on, 7 days off; add progestin on last 10-12 days of cycle after breakthrough bleeding occurs or 2 years of estrogen treatment.
Abnormal uterine bleeding:
1.25 mg twice a day PO for 21 days. May increase to 2.5 mg 2-4 times a day.
Adverse Effect :
Common Reactions: Musculoskeletal, pain, abdominal cramps/distension, dyspepsia, nausea/vomiting, constipation, cervical secretion changes, headache, fluid retention, insomnia, mood changes, vulvovaginal candidiasis, glucose intolerance, weight changes, libido changes, contact lens intolerance, vision changes, rash, melasma/chloasma, alopecia, hirsutism, breast development.
Serious Reactions: Thromboembolism, hypertension, breast cancer, ovarian cancer, endometrial cancer, uterine hyperplasia, fibroid enlargement, hypercalcemia, cholestatic jaundice, gall stones, pancreatitis, hepatic hemangioma enlargement, depression, dementia, migraine, chorea exacerbation, seizure disorder exacerbation, asthma exacerbation, porphyria aggravation, SLE exacerbation, hypersensitivity reaction, anaphylaxis/anaphylactoid reaction, erythema multiforme, erythema nodosum, ischemic colitis, intestinal obstruction, vaginal erosion/ulcer.
Hepatic Dose :
Use is contraindicated with hepatic dysfunction.