Estradiol Vaginal Cream
Indication :
Dosing :
Available as 0.01% cream.
Apply twice a day upto 6 weeks.
Adverse Effect :
Common Reactions: Musculoskeletal, pain, abdominal cramps/distension, dyspepsia, nausea/vomiting, constipation, cervical secretion changes, headache, fluid retention, insomnia, mood changes, vulvovaginal candidiasis, glucose intolerance, weight changes, libido changes, contact lens intolerance, vision changes, rash, melasma/chloasma, alopecia, hirsutism, breast development.
Serious Reactions: Thromboembolism, hypertension, breast cancer, ovarian cancer, endometrial cancer, uterine hyperplasia, fibroid enlargement, hypercalcemia, cholestatic jaundice, gall stones, pancreatitis, hepatic hemangioma enlargement, depression, dementia, migraine, chorea exacerbation, seizure disorder exacerbation, asthma exacerbation, porphyria aggravation, SLE exacerbation, hypersensitivity reaction, anaphylaxis/anaphylactoid reaction, erythema multiforme, erythema nodosum, ischemic colitis, intestinal obstruction, vaginal erosion/ulcer.
Hepatic Dose :
Use is contraindicated with hepatic dysfunction.