Cholic Acid
Mechanism :
Cholic acid, a primary bile acid, enhances bile flow and provides the physiologic feedback inhibition of bile acid synthesis to maintain bile acid homeostasis.
Indication :
- Bile acid synthesis disorders
- Peroxisomal disorders
Contraindications :
No contraindications.
Dosing :
Oral
≥3 weeks:
10 to 15 mg/kg (once daily or in 2 divided doses); administer 11 to 17 mg/kg (once daily or in 2 divided doses) in patients with concomitant familial hypertriglyceridemia.
Adverse Effect :
Cholestasis, hyperbilirubinemia, increased serum transaminases, malaise, peripheral neuropathy, diarrhea, abdominal pain, intestinal polyps, UTI, jaundice, cholelithiasis.
Interaction :
Aluminium Hydroxide: May decrease the absorption of Cholic Acid.
Bile Acid Sequestrants: May decrease the absorption of Cholic Acid.
BSEP/ABCB11 Inhibitors: May decrease the excretion of Cholic Acid.
Sevelamer: May decrease the absorption of Cholic Acid.
Sucralfate: May decrease the absorption of Cholic Acid.
Hepatic Dose :
Discontinue treatment there is clinical or laboratory liver function deterioration or cholestasis.