Cefoperazone

Mechanism :

Cefoperazone is a broad spectrum third generation cephalosporin antibiotic but fails to inhibit beta-lactamase producing microorganisms. It acts by inhibiting cell wall synthesis in susceptible bacteria. It is used in treatment of respiratory tract infections, UTI, peritonitis. It is not very useful in treatment of meningitis as it does not penetrate the blood brain barrier as freely as compared to other third generation cephalosporins. It is available only in the injectable form.

Indication :

Bone and joint infection
Pelvic inflammatory disease
Peritonitis
Respiratory tract infections
Septicaemia
Skin infections
Urinary tract infection.

Contraindications :

Cefoperazone is contraindicated in conditions like Hypersensitivity to any component of product.

Dosing :

100-200 mg/kg/day in 2 divided doses IV/IM for 10-14 days.

Adverse Effect :

Anemia, GI bleeding, hemolytic anemia, leukopenia, lymphocytosis, bone marrow depression, bleeding, dizziness, anorexia, fever, dyspnea, abdominal pain, skin rashes, chills, urticaria, paraesthesia.

Interaction :

Alcohol, Probenecid, Warfarin: Cefoperazone is known to interact with other drugs like Alcohol, Probenecid, Warfarin (Na).

Hepatic Dose :

Dose modification may be necessary in cases of severe biliary obstruction and severe hepatic disease. However, no specific dosage adjustments provided in manufacturer’s label.