Calcitonin

Mechanism :

Calcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland in mammals. Calcitonin acts primarily on bone, but direct renal effects and actions on the gastrointestinal tract are also recognized.

Indication :

• Osteogenesis imperfecta
• Hypercalcemia

Contraindications :

Clinical allergy to calcitonin-salmon. For patients with suspected sensitivity to calcitonin, skin testing should be considered prior to treatment utilizing a dilute, sterile solution of a calcitonin-salmon injectable product.

Dosing :

Adverse Effect :

Flushing of face, edema, dizziness, headache, chills, rash, nausea, vomiting, diarrhea, anorexia, metallic taste, inflammatory reactions at injection site, weakness, tingling of palms and soles, back and joint pain, diuresis, shortness of breath, hypersensitivity reactions.

Interaction :

Cardiac glycosides: Calcitonin may cause serum calcium levels to fall transiently to below normal levels, and therefore dose adjustment of cardiac glycosides may be necessary.

Renal Dose :

Hepatic Dose :