Anti-Thymocyte Immunoglobulin
Synonym :
ATG
Mechanism :
The possible mechanism may involve elimination of antigen-reactive T-lymphocytes (killer cells) in peripheral blood alteration of T-cell function.
Indication :
- Treatment of acute rejection after renal transplant.
- Treatment of aplastic anemia in patients.
Contraindications :
Hypersensitivity to antithymocyte globulin, rabbit proteins or any component; acute viral illness.
Dosing :
Renal transplantation rejection:
IV: 10 to 15 mg/kg/dose once daily for 14 days, then if needed, give alternate day up to a total of 21 doses in 28 days.
Aplastic Anemia:
10-20 mg/kg/day IV for 8-14 days and then every alternate day (total doses 21).
Adverse Effect :
Fever, thrombocytopenia, rash, leukopenia, rigors, infections, arthralgia, headache, diarrhea, hypertension, edema, thrombosis, anaphylaxis, proteinuria, serum sickness.
Interaction :
With other immunosuppressants: Additive immunosuppressive effects or over immunosuppression.
Hepatic Dose :
No dosage adjustments are recommended.