Anti-Rh
Synonyms :
D Immunoglobulin, Human Anti-D Immunoglobulin
Mechanism :
Immune Globulin sterile solutions containing IgG anti-D (anti-Rh) for use in preventing Rh immunization. They are manufactured from human plasma containing anti-D. A single dose contains sufficient anti-D (approximately 300 µg) to suppress the immune response to 15 mL (or less) of Rh-positive red blood cells. The mechanism of action is unknown. Not effective in altering the course or consequences of Rh immunization once it has occurred.
Indication :
- Use after Rh Incompatible Transfusion.
- Rh negative females when they are pregnant with a Rh positive fetus.
Contraindications :
Individuals known to have had an anaphylactic or severe systemic reaction to human globulin should not receive any Rh(D) Immune Globulin (Human).
Dosing :
For prevention of hemolytic disease in newborn:
Antepartum administration: 1500 IU or 300 mcg IV/IM at 28-30 weeks of gestation.
Postpartum: 1500 IU IV/IM within 72 hours (can be given upto 28 days).
Chronic immune thrombocytopenic purpura:
250 IU/kg IV. Infuse IV over 3-5 min.
Incompatible transfusions:
In the event of exposure to Rh (D) positive whole blood: 9-12 mcg (45-60 IU)/mL blood IM.
Adverse Effect :
Swelling, induration, redness and mild pain at the site of injection.
Interaction :
No specific drug interactions reported.
Hepatic Dose :
No dosage adjustments are recommended.