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Posted On : 20 Feb 2017

many literature suggest Deflazacort is better than prednisilone in nephrotic syndrome because little side effect.but no standard text book suggest as drug of choice in nephrotic syndrom _? is it because of cost factor or more studies required_?

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Answer 1

Deflazacort possibly has a small advantage for less decrease in bone mineral density, which can be overcome with calcium supplements in a child on prednisolone. The cost is definetely a factor and since there are no evidence based guidelines proving its superiority, the current recommendations are to use Prednisolone. There are some RCT going on and the situation may alter once we have evidence proving or diproving the superiority

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