Meclofenamate
Mechanism :
Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.
Indication :
- Juvenile arthritis, osteoarthritis and rheumatoid arthritis- pain relief
- Bursitis/tendinitis of the shoulder
- Fever
- Pain relief in primary dysmenorrhea/excessive menstrual blood loss
Contraindications :
Known hypersensitivity to meclofenamate or any component of the formulation; history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Dosing :
>14 years
Pain:
Oral: 200 to 400 mg daily in 3 to 4 equally divided dose maximum dose: 400 mg/day. Maximal benefit may not be seen for 2 to 3 weeks.
Primary dysmenorrhea/excessive menstrual blood loss:
Oral: 100 mg 3 times daily for up to 6 days, starting at the onset of menstrual flow.
Adverse Effect :
Dizziness, skin rash, abdominal cramps, dyspepsia, headache, pruritus, fluid retention, vomiting.
Interaction :
Anticoagulants: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Anticoagulants.
Apixaban: Nonsteroidal Anti-Inflammatory Agents (Nonselective) may enhance the adverse/toxic effect of Apixaban.
Quinolones: Nonsteroidal Anti-Inflammatory Agents may enhance the neuroexcitatory and/or seizure-potentiating effect of Quinolones.
Vancomycin: Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of Vancomycin.
Hepatic Dose :
No dosage adjustments are recommended.