Cerliponase Alfa
Mechanism :
Cerliponase alfa is a proenzyme that, once activated, cleaves tripeptides from the N-terminus of proteins.
Indication :
- Neuronal ceroid lipofuscinosis type 2
Contraindications :
Acute intraventricular access device-related complications, ventriculoperitoneal shunts.
Dosing :
≥3 years:
Intraventricular: 300 mg once every other week.
Adverse Effect :
ECG abnormality, Abnormal proteins in cerebrospinal fluid, seizure, pleocytosis, headache, vomiting, hematoma, hypersensitivity reactions, antibody formation, fever, bradycardia, hypotension, jitteriness, catheter infection.
Interaction :
No known significant interactions.
Hepatic Dose :
No dosage adjustments are recommended.