Cefoperazone - Sulbactam

Mechanism :

It is a combination of the third-generation cephalosporin (cefoperazone) and the beta lactam inhibitors (sulbactam). It is used in treatment of serious respiratory tract infections, UTI, peritonitis, septicemia caused by gram positive, gram negative and anaerobic organisms. It is available only in the injectable form.

Indication :

Bone and joint infection
Pelvic inflammatory disease
Peritonitis
Respiratory tract infections
Septicaemia
Skin infections
Urinary tract infection.

Contraindications :

Hypersensitivity. Known allergy to penicillins.

Dosing :

50-80 mg/kg/day with reference to cefaperazone in 2-4 divided doses IV/IM for 10-14 days.

Adverse Effect :

Anemia, GI bleeding, hemolytic anemia, leukopenia, lymphocytosis, bone marrow depression, bleeding, dizziness, anorexia, fever, dyspnea, abdominal pain, skin rashes, chills, urticaria, paraesthesia.

Interaction :

Aminoglycosides: Concomitant admin may increase risk of nephrotoxicity.
Heparin/Warfarin: Concurrent use may cause marked hypoprothrombinemia and/or prolonged bleeding time.

Hepatic Dose :

Dose modification may be necessary in cases of severe biliary obstruction, severe hepatic disease. However, no specific dosage adjustments provided in manufacturer’s label.