Anti-Rabies Immunoglobulin

Synonyms :

HRIG, Human Rabies Immunoglobulin, Rabies Immunoglobulin

Mechanism :

Rabies immunoglobulins provide passive immunity to rabies. 2 types of immunoglobulin are available namely, human rabies immunoglobulin (HRIG) and purified equine rabies immunoglobulin (ERIG). HRIG is prepared from the plasma of human donors hyperimmunised with rabies vaccine and is preferred over ERIG.

Indication :

Suspected rabies exposure type III.

Contraindications :

Repeated doses of rabies immunoglobulin Should not be given once rabies vaccine is administered as this may reduce the immunologic response to the vaccine.

Dosing :

Along with rabies vaccine in previously unvaccinated individuals: HRIG 20 IU/kg (immediately or within 7 days of exposure) infiltrated in and around the bite site; any remainder to be injected via IM injection in area distant to that of vaccine inoculation.

Previously vaccinated individuals with adequate rabies antibody titre: HRIG not required. Give only the rabies vaccine.

Adverse Effect :

Soreness at injection site, headache, fever, chest or joint pain, dyspnea, tremor, dizziness, edema of the face, glossitis, buccal ulceration, hematuria, bruising, sunburn, sterile pyuria, anaphylactic reaction.

Interaction :

Live Virus Vaccine (e.g. measles, mumps, rubella and varicella): Decreased response; administration at least 4 months after human rabies immunoglobulin administration.

Hepatic Dose :

No dosage adjustments are recommended.