Abatacept
Indication :
- Juvenile Idiopathic Arthritis
Dosing :
>2 years:
10 to 24 kg: 50 mg SC once weekly.
25 to 49 kg: 87.5 mg SC once weekly.
50 kg and above: 125 mg SC once weekly.
In children >6 years can also be given IV: 10 mg/kg over 30 mins followed by repeat dose
2 and 4 weeks after initial dose. Then give once in 4 weeks.
Adverse Effect :
Headache, URI, nausea, infections, back pain, hypertension, rash, body pain, hypersensitivity.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function. Use with caution |
| <10 | Dose as in normal renal function. Use with caution |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Unlikely to be dialysed. Dose as in GFR<10 mL/min |
| HD | Unlikely to be dialysed. Dose as in GFR<10 mL/min |
| HDF/High flux | Unlikely to be dialysed. Dose as in GFR<10 mL/min |
| CAV/VVHD | Unlikely to be dialysed. Dose as in GFR=10–20 mL/min |
Hepatic Dose :
No dosage adjustments are recommended.