4th Pediatric Infectious Diseases Conference
 
 
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NUTRITION IN CHILDREN
NUTRITION FOR HEALTHY GROWTH AND IMMUNITY
Nutrition for Healthy Growth and ImmunityNutrition for Healthy Growth and Immunity
Nutrition for Healthy Growth and Immunity
NUTRITION & IMMUNE SYSTEM
Nutrition has a two-way influence on the immune system. The activities of the immune system exert a deleterious influence on nutritional status and alterations in nutrient intake modulate the intensity of the various activities of immune system.(1)

Effect of infection on nutrition :-
With infection, muscle protein is catabolized to provide amino-acids to form new cells and proteins for immune response. Fat is also catabolised and fatty acids are released to satisfy increased energy requirements of infected person.

Gluconeogenesis also serves as a pathway for energy. Iron, copper & zinc are released from tissues to help wound healing. Acute phase reactant proteins are released that help in immunomodulation.

Effect of nutrition on immune system :-
Malnutrition influences virtually all of the components of the immune system with reduction of cell number and function of T-cell lymphocytes, shrinkage or impaired development of lymphoid organs (thymus, spleen and gut associated lymphoid tissue) and suppression of some aspects of inflammatory response.(1) Total food deficit can lead to reversal of CD4:CD8 ratio and decrease plasma complement level. Protein energy deficit can suppress humoral and cell mediated response, decrease tissue repair and macrophage functions. Arginine deficiency can impair T-cell growth and development as well as thymic integrity whereas glutathione deficiency can decrease oxidant properties of leukocytes. Nucleic acid deficiency can suppress natural killer cell activity and cell mediated immunity whereas impair recovery from sepsis. Supplementation of n-3 PUFA can decrease inflammation whereas saturated fatty acids can lead to immunosuppression. Copper & zinc deficiency also impair T-cell function and super oxide dismutase activity.(10) In animal models, deficiency of vitamin E & A can impair both humoral and cell-mediated responses.

Thus, nutrition is an important determinant of immune responses. Nutritional deficiencies alter immunocompetence and increase risk of infection which in turns leads to poor appetite and a vicious cycle.
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