4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
Hi, I have a few patients with cardiomyopathy secondary to cardiac siderosis (B thal patients)I am planning to start them on continuous infusion of deferral since they are in heart failure. what would be the method to do that?
Answer
Deferoxamine 25-50 mg/kg over 8-12 hours as a subcutaneous infusion at least 5 nights per week is recommended. 2.5-3.0 gm is probably the maximal tolerated amount for subcutaneous infusion. Each 500 mg of Deferral should be diluted in a minimum of 2 ml preservative free water. DF should be given in areas with the most subcutaneous fat, such as the abdomen, thighs, upper arms, or buttocks. Infusion sites should be rotated to a different place each day. To avoid bone infections, thin individuals should avoid inserting the needle near bony prominences. The infusion needle should be inserted at a 45 degree angle.

Vitamin C(ascorbic acid) mobilizes iron from tissues. Doses > 500 mg/day have been associated with worsening of cardiac dysfunction in patients with severe iron overload.
 
 
 
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Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
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