4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
A 10 yr female with complains of---- 1} virilization ---- deep voice , excess facial hairs , clitoris enlarged 2} headache in the occipital region 3} generalized weakness [ virilizing changes noticed around 5-6 yrs of age] PAST HISTORY--- fever with convulsion at 2 yr of age, hospitalized for 5 days ON EXAMINATION --- wt & ht normal p -- 102/min menarche not attained r/r -- 24/min generalized skin hyperpigmentstion (+) bp -- 100/70 mmhg breast- prepubertal RS/CVS/CNS-- NORMAL EXTERNAL GENITALS-- dense pubic hairs with significant clitoris enlargement. few I/G done 3-4 yrs back--- 1] mri brain-- microadenoma in anterior pitutary 2] serum estrogen & progestrone -- normal 3] usg abdo-- uterus/ovary normal Q1-how to corelate pitutary adenoma with virilization? Q2-how to further investigate this pt? Q3- what should be the plan of management? Please help me sir to understand this case. Thank you sir.
Answer
This virilization could be due to the adrenals. Rule out congenital adrenal hyperplasia (CAH).

Read the articles on INTERSEX DISORDERS AND CAH on www.pediatriconcall.com or from the link given below:

http://www.pediatriconcall.com/fordoctor/ diseasesandcondition/
Endocrine_disorders/intersex_disorders.asp



http://www.pediatriconcall.com/fordoctor/casereports/
CONGENITAL_ADRENAL_HYPERPLASIA.asp

 
 
 
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Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
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