4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
Of late, drug companies are promoting bovine colostrum preparations to improve immunity status of chronically ill children; even claiming that it will help the asthmatics; is there real proof that these supplements are really useful?
Answer
Well-designed, controlled clinical trials of bovine colostrum are largely lacking. A few human studies have suggested that some components of some bovine colostrum preparations have significant antimicrobial activity. Immunoglobulins in colostrum derived from cows immunized against particular pathogens may help protect against those specific pathogens in some instances, but bovine colostrum supplements may vary widely in terms of specific constituents.

Ref:
Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Crytosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquired Immune Deficiency Syndrome Hum Rretrovirol. 1996; 13:348-354.

Huppertz HI, Rutkowski S, Busch DH, et al. Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin-producing E. coli, and E. coli expressing intimin and hemolysin. J Pediatr Gastroenterol Nutr. 1999; 29:452-456.
 
 
 
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Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
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