4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
Respected sir, I AM FORWARDING HERE WITH my query and your answer to that. Please refer to the second question. I have asked to you regarding which I am writing. What is side effect of NEVIRAPINE. IN OUR PROJECT WE ARE GIVING 6 WEEKS NEVIRAPINE ONLY TO PCR NEGATIVE babies and not as ART TO positive babies. My Q was in our project many babies got neutropenia. As GRANULOCYTOPENIA has been mentioned as very rare side effect and that also in very few articles.So does nevirapine really leads to neutropenia. Sorry for asking the Question again.
Answer
Neutropenia is a rare side effect of NVP. A recent study of nevirapine prophylaxis in breast-feeding infants reported several cases of neutropenia in clinically-well infants. These low absolute neutrophil counts may have reflected 'ethnic neutropenia', rather than drug toxicity. This phenomenon has not been confirmed to exist in African infants.

Ref:
Antivir Ther. 2003; 8 (Suppl.1): abstract no. 1039.
 
 
 
Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
Educational Section
 
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