4th Pediatric Infectious Diseases Conference
 
 
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Specialist Answers
Question
How do salicylate ingestion lead to raised levels of serum uric acid?? What is the mechanics?
Answer
Aspirin (and other salicylates) have varying effects on uric acid. Uric acid is handled by the kidney in a very complicated pattern. After being filtered through the glomerulus, the uric acid ia almost all reabsorbed from the urine, then is secreted back into the urine, with a small amount then being reabsorbed once again. At low aspirin levels (as may occur in persons taking aspirin only occasionally), aspirin blocks secretion of uric acid by the kidneys and can increase blood uric acid. On the other hand, in high doses (as may be used to treat rheumatoid arthritis), aspirin blocks are absorption of uric acid by the kidneys to a greater extent than it blocks secretion, leading to lower uric acid.
 
 
 
Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
Educational Section
 
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