Rubella Infection - Pediatric Oncall

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Rakesh Kumar, Binay Ranjan, Manjul Vijay Department of Pediatrics, Katihar medical college, Katihar...

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Question
My wife is pregnant for three months. (Last period was on MAY 16th 2007.)She had some Rashes and mild fever for three days on 11-June 2007. We suspected German measles infection and tested for TORCH on 11-August 2007 (two months after the rashes and fever appeared) the result was ELISA for RUBELLA IgG Antibody: POSITIVE >250 IU/ml ELISA for RUBELLA IGM Antibody : NEGATIVE The gynecologist said she had no problem / no infection. I heard the Rubella infection is a high risk for the unborn and and hence again we did the Rubella test on 4-Sept -2007 the result was RUBELLA IgG Antibody (ELFA) :POSITIVE >400 UI/ml RUBELLA IGM Antibody (ELFA) : NEGATIVE My concerns are is there any risk for the unborn? How long will the IgM antibodies be present in the body, if she had an infection? Is there is any way we can find a recent rubella infection (within 3- 4 months)? Can you give any suggestions if it was a rubella infection? Thanking you a lot.
Answer
Usually presence of Rubella IgM or 4 fold rise in IgG (done after 4 weeks) is suggestive of recent infection. In your wife's case though the IgG has risen, it is not a fourfold rise. Also IgM is negative. The presence of Rubella IgG may be due to previous vaccination with MMR or rubella vaccine. Since she had fever with rash, you may do a Rubella PCR to check if she has recent infection with rubella. Back to All Questions

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