4th Pediatric Infectious Diseases Conference
 
 
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Autoimmune Disorder
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Specialist Answers
Question
How do you treat haemophagocytic syndrome and how do u follow up such patients?
Answer
Hemophagocytosis can occur as a result of multiple etiologies: viral, bacterial, parasitic (Infectious), malignant, autoimmune, and familial. Hemophagocytic syndromes are associated with a high mortality (30-45%) dependent on etiology and degree of associated organ failure. Malignancy associated and familial hemophagocytic syndromes have a worse prognosis than infection associated.


In general therapy is supportive with treatment of the underlying disorder. High dose corticosteroids, immunoglobulins, plasmapheresis and other immue-modulating treatments such as etoposide are used in treatment. One would need to monitor CBC, liver function tests, renal function tests and clinical examination serially to assess improvement. Occasionally a bone marrow may be required to check for hemophagocytes in marrow. Other parameters such as fibrinogen, triglycerides, cholesterol, ferrtin etc should also be monitored.
 
 
 
Pedi Poll
Today's Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
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