LEUKODYSTROPHIES - MRI
Last Updated : 1/7/2011
Priya Chudgar
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Checklist
- Location of white matter abnormalities
- Signal of white matter apart from the affected regions (

hypomyelination

)
- Cavitation
- Cerebellar involvement
- Head size
- Contrast enhancement

Characteristic features of various leukodystrophies on MRI
- Macrocephaly is seen in Krabbe's, Alexander's, Canavan's, Hurler syndrome
- White matter changes located posteriorly: ALD
- White matter changes located anteriorly: Alexander's disease
- Periventricular involvement: MLD, ALD
-

Involvement of arcuate fibers

: Canavan's disease
- High density basal ganglia: Krabbe's disease
- Post contrast enhancement is seen in ALD, Alexander

Alexander's Disease (Fig 1)


MLD (Fig 2)
MLD (Fig 2a)


ALD (Fig 3)
ALD (Fig 3)


Infantile onset leukoencephalopathy (Vacuolation/spongiform changes) (Fig 4)
Infantile onset leukoencephalopathy (Vacuolation/spongiform changes) (Fig 4a)




Contributor Information and Disclosures

Priya Chudgar
Lecturer in Radiology, Department of Radiology, KEM Hospital, Mumbai, India


First Created : 1/10/2001

References

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