CONGENITAL LEUKEMIA & HYPOPLASTIC PRELEUKEMIA
Last Updated : 1/4/2011
Bharat R Agarwal
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CONGENITAL LEUKEMIA

Leukemia

diagnosed from birth to 6 weeks of age is defined as congenital leukemia. This is a rare disease. Its etiology is unknown. Congenital leukemia has been associated with:
- Trisomy 7
- Turner's syndrome
- Mosaic trisomy 9
- Mosaic monosomy 7
A few examples of congenital JMML have been reported.

HYPOPLASTIC PRELEUKEMIA
A small number of patients who ultimately develop acute leukemia are initially diagnosed as having aplastic anemia.

The illness is characterized by

:
-

Pancytopenia or single cytopenia


-

Hypocellular bone marrow


-

No hepatosplenomegaly



Diagnosis of leukemia 1-9 months after onset of symptoms.
In 1-2% of childhood leukemias, the presentation includes initial marrow failure and may represent 5% of childhood acquired aplastic anemia.



Contributor Information and Disclosures

Bharat R Agarwal
Pediatric Hematologist-Oncologist, Division of Pediatric Hem-Onco, B.J. Wadia Hospital for Children, Mumbai, India.


First Created : 1/4/2001

References

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