STEVENS JOHNSONS SYNDROME AND TOXIC EPIDERMAL NECROLYSIS
Last Updated : 1/2/2014
Neha Bansal
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What is

Stevens Johnson syndrome (SJS) and toxic epidermic necrolysis (TEN)

?

It is an adverse cutaneous drug reaction and a complex immunological complex also, involving atleast 2 mucous membranes. (1, 2) It is called erythema multiforme major and causes acute blistering. The skin detachment is <30% in SJS and more extensive in TEN. (2)

What are the

causes of Stevens Johnson syndrome (SJS) and toxic epidermic necrolysis (TEN)

?

The commonest causes are listed below:

1. Infections

: Herpes simplex virus (HSV), Mumps

2. Drugs

: large list including NSAIDs, Antibiotics, anticonvulsants (4)

3. Genetic

: seems to be more common in certain populations like East asian

What is the

pathogenesis of Stevens Johnson syndrome (SJS) and toxic epidermic necrolysis (TEN)

?

It is not clearly understood. However, recently there is increased understanding in the apoptotic pathway of the keratinocytes and the immunological changes and the processes that lead to this adverse drug reaction. (4)

References

Contributor Information and Disclosures

Neha Bansal
MBBS, KEM Hospital, Mumbai, India


First Created : 1/24/2013

References

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