Hepatosplenomegaly with bicytopenia
Author: Pediatric Oncall
Question.
A 2 years old girl presented with lump on left side of abdomen for 6 months. There was no pallor or jaundice. On examination, she had splenohepatomegaly with palmar erythema and cervical adenopathy. Weight was 8 kg.
• She had anemia and thrombocytopenia with peripheral smear suggestive of either blast like cells or atypical lymphocytes.
• Her direct and indirect Coombs test was negative.
• SGOT was 88 IU, L, SGPT = 71 IU, L.
• USG abdomen showed hepatosplenomegaly with intra abdominal lymphnodes and splenic microabscess.
• Bone marrow biopsy showed mature B cell lymphocytosis with relative erythroblastopoiesis and megakaryocytes were seen. There were no blasts or abnormal cells.
• Lymphnode biopsy was suggestive of viral induced lymphadenopathy.
• Epstein Barr Virus {EBV} VCA IgM was negative.
• HIV ELISA was negative.
• S.immunoglobulins showed increased serum IgG.
• Lymphocyte subset analysis showed increased CD19, CD3 and CD4 cells.
• Liver biopsy showed intraepithelial lymphocytosis suggestive of either hepatitis C infiltration or autoimmune hepatitis.
• Her Hepatitis C ELISA was negative and Anti Liver Kidney Microsomal {LKM}, ANA and anti smooth muscle antibody were negative.

Answers of this discussion
Author :- huda esoulc on 26 January 2013.
Answer :- chronic granulomatous disease

Author :- Rolando Lezama on 29 January 2013.
Answer :- autoimmune hepatitis

Author :- Rolando Lezama on 29 January 2013.
Answer :- autoimmune hepatitis

Author :- Pramod Kulkarni on 31 January 2013.
Answer :- hepatosplenomegaly,anemia,thrombocytopenia,splenic microabscesses on USG.... fever_?wt.loss_?joint manifestations_?h, o-animal exposure, raw milk ingestion_? brucellosis to be excluded.. Mantoux_?portal vein size_?

Author :- sree harsha on 02 February 2013.
Answer :- HIV PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

Author :- rajiv malic on 05 February 2013.
Answer :- MDS r

Author :- Awais Tahir on 07 February 2013.
Answer :- rule out disseminated tuberculosis.. and neutrophil function defects

Author :- elsayed aly elsayed on 08 February 2013.
Answer :- lymphoma

Author :- shruticash on 09 February 2013.
Answer :- histiocytosis

Author :- Kamiludeen Hassan on 09 February 2013.
Answer :- infectious mononucleosis

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