4th Pediatric Infectious Diseases Conference

 
 
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POISIONING CENTER
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FIND DIAGNOSIS
FIND DIAGNOSIS
FIND DIAGNOSIS
POISIONING CENTER
 
Nicotine (Tobacco)
 
The dried leaves are used as article of luxury by almost all classes of people in the form of smoke, snuff or chewing

Route : Inhalation, ingestion or absorption from skin

Fatal dose : 1-2 drops of pure nicotine; 15-30gms of crude tobacco

Fatal Period : 1-2 drops of pure nicotine; 15-30gms of crude tobacco

Mechanism of action : Active principle: Nicotine and nicotinanine

Mechanism of action: It stimulates and then depresses and later paralysis the cells of peripheral ganglion, brain {especially mid brain} and spinal cord. Skeletal muscles including the diaphragm are paralysed.


Clinical picture : •Burning and acid sensation in upper GIT
•GIT irritation
•Giddiness, faintness, numbness, muscle weakness, tremors, cold clammy skin, unconsciousness
•Confusion and incoordination
•Pupils constricted initially, later dilated
•Pulse, BP and respiration are increased
•Chronic smoking in heavy smokers and those working in tobacco industries


Treatment : •Stomach wash
•Purgatives
•Antidote: Mecamylamine is given orally
•Injection atropine
•Symptomatic


 
 
 
 
Pedi Poll
Today’s Poll
Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
No, it should be used only after drug sensitivity report
Yes, under guidance of an infectious disease expert
 
Educational Section
 
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