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Chemotherapy- General Guidelines
Chemotherapy- General Guidelines
Chemotherapy- General Guidelines
Chemotherapy- General Guidelines
Chemotherapy - General Guidelines
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Should teicoplannin, colistin be used in case of neonatal sepsis where culture does not reveal any organism_?
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Yes, under guidance of an infectious disease expert
CHEMOTHERAPY- GENERAL GUIDELINES
Chemotherapy- General Guidelines
Dr Ira Shah
M.D, DCH (Gold Medalist), FCPS, DNB
Edited by Dr. Bharat R Agarwal
Consultant Pediatric Hematologist and Oncologist.


Q.What are the various types of chemotherapeutic drugs?

A. The various anticancer drugs are classified as:
  • Alkylating agents -
    • Chlorambucil
    • Ifosfamide
    • Mechlorethamine
    • Cyclophosphamide
      Other agents with alkylator activity are :-
    • Carboplatin
    • Cisplatin
    • Procarbazine
    • Dacarbazine
    • Carmustine, etc.

  • Antimetabolites - Cytosine (Cytarabine, Ara-C)
    • Hydroxyurea
    • Mercaptopurine
    • Methotrexate
    • Thioguanine
    • 5- Fluoro uracil.

  • Antibiotics - Actinomycin D,
    • Bleomycin,
    • Daunorubicin,
    • Doxorubicin,

  • Alkaloids - Etoposide,
    • Vinblastine
    • Vincristine

  • Other agents - L-asparaginase,
    • Adrenocorticosteroids

Q. How do these agents act?

A. Most chemotherapeutic agents exert their major toxic and anti-tumor effect by inhibiting the DNA synthesis of malignant and dividing cells. Hence, bone marrow and intestinal mucosa suffer the most toxicity.

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